Rheumatoid Arthritis Research Today is a free monthly online journal that collates and summarizes the latest research about Rheumatoid Arthritis, including details on treatment, symptoms, causes, medication.

The different stages of synovitis: acute vs chronic, early vs late and non-erosive vs erosive.

Tarner IH, Härle P, Müller-Ladner U, Gay RE, Gay S

Department of Internal Medicine I, University Hospital Regensburg, D-93042 Regensburg, Germany.

Rheumatoid arthritis is a systemic inflammatory disease that, by definition, can affect all parts of the human body, including severe complications such as uveitis/episcleritis and vasculitis of the heart, lungs, kidneys and the central and peripheral nervous systems. Its primary and by far the most common manifestations, however, affect the joints and are characterised by inflammatory reactions and activation of the synovial lining tissue and associated structures, the latter resulting in tenovaginitis and rheumatoid nodules. As all pathophysiological mechanisms are based on pathways that are inherent in the different components of a joint, it is necessary to examine the unique features of normal synovium prior to analysing disease-specific pathways. This chapter will therefore describe the physiological structure of the synovium and the inflammatory pathology of rheumatoid synovitis in early and chronic stages of the disease.

Published 13 December 2004 in Best Pract Res Clin Rheumatol, 19(1): 19-35.
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